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  "Title": "Model Fitting and Simulation for Drug Release Kinetics and PK/PD",
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  "Author": "Paul Angelo C. Manlapaz [aut, cre] (ORCID:\n<https://orcid.org/0000-0002-1203-2064>)",
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  "Description": "Provides a comprehensive framework for model fitting and\nsimulation of drug release kinetics, pharmacokinetics (PK), and\npharmacodynamics (PD). The package implements widely used\nmechanistic and empirical models for in vitro drug release,\nincluding zero-order, first-order, Higuchi, Korsmeyer-Peppas,\nHixson-Crowell, and Weibull models. Pharmacokinetic\nfunctionality includes linear and nonlinear functions for one-\nand two-compartment models for intravenous bolus and oral\nadministration, Michaelis-Menten kinetics, and\nnon-compartmental analysis (NCA). Pharmacodynamic and\ndose-response modeling is supported through Emax-based models,\nincluding stimulatory (sigmoid Emax) and inhibitory (sigmoid\nImax) Hill models, four- and five-parameter logistic models, as\nwell as median toxic dose (TD50) and lethal dose (LD50) models.\nThe package is intended to support parameter estimation,\nsimulation, and model comparison in pharmaceutical research,\ndrug development, and pharmacometrics education. For more\ndetails, see Gabrielsson & Weiner (2000) <ISBN:9186274929>,\nHolford & Sheiner (1981)\n<doi:10.2165/00003088-198106060-00002>, and Manlapaz (2025)\n<doi:10.32614/CRAN.package.adsoRptionCMF>.",
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